Cooper Kupp has had 55 catches for 558 yards and has scored 3 touchdowns in 10 games against the 49ers in his career.

Chris Johnson has the most rushing yards + receiving yards in a season, with 2,509 in 2009.

The Indianapolis Colts are 11-9-1 in the regular-season and playoffs versus the Lions on the road all-time.

The Indianapolis Colts have a 22-20-2 record in the regular-season and playoffs versus the Lions all-time.

Saquon Barkley had the most rushing yards + receiving yards this season, with 2,283.

Kordell Stewart had his most passing yards in a game against the Eagles on November 23, 1997, with 294 yards.

The Indianapolis Colts have an 18-8 record against the NFC North in the regular-season and playoffs all-time.

Since 2010, Frank Gore has the most rushing yards by a player older than 30, with 6,033 yards.

Ben Roethlisberger had his most passing yards in a game against the Eagles on September 25, 2016, with 257 yards.

The Indianapolis Colts have a 9-5 record against the NFC North in the regular-season and playoffs on the road all-time.

Puka Nacua has had 26 catches for 285 yards and has scored 1 touchdown in 3 games versus the 49ers in his career.

The Philadelphia Eagles had a 14-3 record in 2022.

The Indianapolis Colts have a record of 18-8 against the NFC North in the regular-season and playoffs all-time.

Since 1996, the New England Patriots have the best record by a team, with a record of 308-160.

Wide receivers caught 63.6 percent of targets this season.