Advanced Micro Devices (AMD) had the highest return between December 17, 2015 and December 18, 2016 by a US stock in the S&P 500 (GSPC), returning 323%.
The closing price for Bitcoin (BTC) in terms of GBP in 2010 was 0.19, on December 31, 2010. It was up 242.6% for the year. The latest price is 54,627.19.