Molson Coors Beverage (TAP.A) had the lowest return in 2006 by a large-cap US stock, returning -100%.

PulteGroup (PHM) had the lowest return in 2007 by a large-cap US stock, returning -67.9%.

American International (AIG) had the lowest return in 2008 by a large-cap US stock, returning -97.3%.

Genmab A-S (GMAB) had the lowest return in 2009 by a large-cap US stock, returning -60%.

Booking (BKNG) had the lowest return in 2000 by a large-cap US stock, returning -97.5%.

Juniper Networks (JNPR) had the lowest return in 2001 by a large-cap US stock, returning -84.7%.

Nio Inc Class A ADR (NIO) had the highest return in 2020 by a large-cap US stock, returning 1,088.8%.

The closing price for Bitcoin (BTC) in 2021 was $46,306.45, on December 31, 2021. It was up 59.7% for the year. The latest price is $65,741.19.

Between September 7, 1981 and September 7, 2024, Bitcoin (BTC) has returned 108,987,278.3% and SPY has returned 2,087.2%.

Fresh2 (FRES) had the best year in 2020 by a US stock in 2020, returning 1,882,670.9%.

Advanced Micro Devices (AMD) had the highest return between December 20, 2018 and May 31, 2019 by a mega-cap US stock, returning 51.4%.

Baidu (BIDU) had the highest return between March 20, 2006 and August 20, 2006 by a large-cap US stock, returning 62.7%.

Natwest (NWG) had the highest return between March 20, 2006 and June 20, 2008 by a large-cap US stock, returning 9,812,033.3%.

Sorry, I don't have the answer to that one.

Mastercard (MA) had the highest return between March 20, 2006 and June 21, 2007 by a large-cap US stock, returning 310.1%.