Doug Martin earned the most fantasy points in a game in 2012, with 51.2 points against the Oakland Raiders on November 4, 2012.

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Jamaal Charles collected the most fantasy points in a game in 2013, with 51.5 points versus the Oakland Raiders on December 15, 2013.

Ben Roethlisberger had the most fantasy points in a game in 2014, with 44.8 points against the Colts on October 26, 2014.

Le'Veon Bell earned the most fantasy points in a game in 2016, with 47.8 points against the Bills on December 11, 2016.

Drew Brees collected the most fantasy points in a game in 2015, with 46.3 points versus the Giants on November 1, 2015.

Breece Hall had 10.5 fantasy points against the Texans, rushing for 74 yards.

Todd Gurley had the most fantasy points in a game in 2017, with 42 points versus the Seahawks on December 17, 2017.

Joe Mixon is one of only 3 running backs with four 100-yard rushing games, along with Derrick Henry and Saquon Barkley. He had 23.4 fantasy points against the Colts in Week 8, rushing for 102 yards and 1 touchdown. He is projected to put up 18.4 fantasy points against the Jets which makes him RB6 this week.

Derrick Henry had the most fantasy points in a game in 2018, with 47.8 points against the Jaguars on December 6, 2018.

Aaron Rodgers had the most fantasy points in a game in 2019, with 43.8 points versus the Oakland Raiders on October 20, 2019.

Ja'Marr Chase has the most fantasy points by a wide receiver this season, with 110.5 points.

Alvin Kamara racked up the most fantasy points in a game in 2020, with 53.2 points against the Vikings on December 25, 2020.

Jonathan Taylor collected the most fantasy points in a game in 2021, with 50.4 points versus the Bills on November 21, 2021.

Joe Mixon had the most fantasy points in a game in 2022, with 51.1 points versus the Panthers on November 6, 2022.