The Buffalo Bills are 3-0 against the 49ers between January 8, 2016 and January 8, 2026.

The Buffalo Bills were 7-9 in 2016. They finished 3rd in the AFC East and 11th in the AFC.

The Buffalo Bills have an 8-6 record versus the 49ers all-time.

T.Y. Hilton had the most yards on receptions in 2016, with 1,448 yards.

Jaxon Smith-Njigba has the most yards on receptions this season, with 1,709 yards.

Jaxon Smith-Njigba has the most receiving yards this season, with 1,709 yards.

Jaxon Smith-Njigba had the most receiving yards this season, with 1,793 yards.

Drew Brees had a passer rating of 94.5 with 1,616 yards, 11 touchdowns and 5 interceptions in 6 games versus the Chiefs on the road in his career.

Marcus Mariota has a passer rating of 90.0 with 1,618 yards, 9 touchdowns and 6 interceptions in 8 games versus the Colts in his career.

Drew Brees had a passer rating of 92.9 with 2,954 yards, 23 touchdowns and 10 interceptions in 11 games versus the Chiefs in his career.

Drew Brees seasons

David Johnson had 124 carries for 409 yards and scored 4 touchdowns in 8 games against the Seahawks in his career.

Mike Wallace had 40 catches for 472 yards and scored 3 touchdowns in 7 games versus the Jets in his career.

Doug Baldwin had 67 catches for 913 yards and scored 4 touchdowns in 16 games against the Cardinals in his career.

Delanie Walker had 62 catches for 624 yards and scored 4 touchdowns in 12 games versus the Colts in his career.