Russell Wilson ran for 5 yards against the Cardinals on January 9, 2022.

buffalo bills game log vs san francisco 49ers at home

The Buffalo Bills have a 1-0 record against the 49ers between December 11, 2020 and December 11, 2025.

The Buffalo Bills are 4-2 against the 49ers at home all-time.

The Buffalo Bills have a 3-0 record versus the 49ers between December 11, 2015 and December 11, 2025.

The Buffalo Bills were 7-9 in 2016. They finished 3rd in the AFC East and 11th in the AFC.

The Buffalo Bills have a record of 8-6 versus the 49ers all-time.

T.Y. Hilton had the most receiving yards in 2016, with 1,448 yards.

Jaxon Smith-Njigba has the most yards on receptions this season, with 1,709 yards.

Drew Brees home and road splits for the last 5 seasons

Ja'Marr Chase had the most receiving yards in 2024, with 1,708 yards.

Ja'Marr Chase had the most yards on receptions in 2024, with 1,708 yards.

Drew Brees had a passer rating of 94.5 with 1,616 yards, 11 touchdowns and 5 interceptions in 6 games versus the Chiefs on the road in his career.

Marcus Mariota has a passer rating of 90.0 with 1,618 yards, 9 touchdowns and 6 interceptions in 8 games versus the Colts in his career.

Drew Brees had a passer rating of 92.9 with 2,954 yards, 23 touchdowns and 10 interceptions in 11 games versus the Chiefs in his career.