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LeSean McCoy got his most total touchdowns in a game on October 16, 2016, on December 18, 2011 and on September 19, 2010, with 3 touchdowns.

what are the most touchdowns in a game by lesean mccoy
Interpreted as:
What are the most touchdowns in a regular-season game by LeSean McCoy?
10/16/2016McCoy12/18/2011McCoy9/19/2010McCoy9/22/2019McCoy11/11/2018McCoy12/17/2017McCoy11/19/2017McCoy10/22/2017McCoy12/18/2016McCoy11/27/2016McCoy9/25/2016McCoy12/22/2013McCoy12/8/2013McCoy11/17/2013McCoy10/28/2012McCoy12/11/2011McCoy12/1/2011McCoy10/30/2011McCoy9/18/2011McCoy9/11/2011McCoy12/2/2010McCoy12/1/2019McCoy3332222222222222222221
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.

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