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LeSean McCoy got his most total touchdowns in a game on October 16, 2016, on December 18, 2011 and on September 19, 2010, with 3 touchdowns.

what are the most touchdowns in a game by lesean mccoy
Interpreted as:
What are the most touchdowns in a regular-season game by LeSean McCoy?
10/16/2016McCoy12/18/2011McCoy9/19/2010McCoy9/22/2019McCoy11/11/2018McCoy12/17/2017McCoy11/19/2017McCoy10/22/2017McCoy12/18/2016McCoy11/27/2016McCoy9/25/2016McCoy12/22/2013McCoy12/8/2013McCoy11/17/2013McCoy10/28/2012McCoy12/11/2011McCoy12/1/2011McCoy10/30/2011McCoy9/18/2011McCoy9/11/2011McCoy12/2/2010McCoy12/1/2019McCoy3332222222222222222221
NAMETDDATETMOPPRUSH TDREC TDRET TDFGMXPMXP2SFTYPTS
LeSean McCoyLeSean McCoy310/16/2016
BUFBUF
vs
SFSF
300000018
LeSean McCoyLeSean McCoy312/18/2011
PHIPHI
vs
NYJNYJ
300000018
LeSean McCoyLeSean McCoy39/19/2010
PHIPHI
@
DETDET
300000018
LeSean McCoyLeSean McCoy29/22/2019
KCKC
vs
BALBAL
110000012
LeSean McCoyLeSean McCoy211/11/2018
BUFBUF
@
NYJNYJ
200000012
LeSean McCoyLeSean McCoy212/17/2017
BUFBUF
vs
MIAMIA
110000012
LeSean McCoyLeSean McCoy211/19/2017
BUFBUF
@
LACLAC
110000012
LeSean McCoyLeSean McCoy210/22/2017
BUFBUF
vs
TBTB
200000012
LeSean McCoyLeSean McCoy212/18/2016
BUFBUF
vs
CLECLE
200000012
LeSean McCoyLeSean McCoy211/27/2016
BUFBUF
vs
JAXJAX
200001014
LeSean McCoyLeSean McCoy29/25/2016
BUFBUF
vs
ARIARI
200000012
LeSean McCoyLeSean McCoy212/22/2013
PHIPHI
vs
CHICHI
200000012
LeSean McCoyLeSean McCoy212/8/2013
PHIPHI
vs
DETDET
200000012
LeSean McCoyLeSean McCoy211/17/2013
PHIPHI
vs
WASWAS
200000012
LeSean McCoyLeSean McCoy210/28/2012
PHIPHI
vs
ATLATL
110000012
LeSean McCoyLeSean McCoy212/11/2011
PHIPHI
@
MIAMIA
200000012
LeSean McCoyLeSean McCoy212/1/2011
PHIPHI
@
SEASEA
110000012
LeSean McCoyLeSean McCoy210/30/2011
PHIPHI
vs
DALDAL
200000012
LeSean McCoyLeSean McCoy29/18/2011
PHIPHI
@
ATLATL
200000012
LeSean McCoyLeSean McCoy29/11/2011
PHIPHI
@
STLSTL
110000012
LeSean McCoyLeSean McCoy212/2/2010
PHIPHI
vs
HOUHOU
110000012
LeSean McCoyLeSean McCoy112/1/2019
KCKC
vs
OAKOAK
10000006
LeSean McCoyLeSean McCoy111/18/2019
KCKC
@
LACLAC
10000006
LeSean McCoyLeSean McCoy19/29/2019
KCKC
@
DETDET
10000006
LeSean McCoyLeSean McCoy112/30/2018
BUFBUF
vs
MIAMIA
10000006
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
LeSean McCoyLeSean McCoy
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.

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