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Drew Brees had the most games with 300+ passing yards, with 123 games.

who has the most career 300 passing yard games
Interpreted as:
Who has the most career 300 or more passing yard regular-season games?
BreesBradyManningRyanRiversRodgersRoethlisbergerStaffordMarinoFavreCousinsPalmerWarnerManningFoutsMoonMahomesRomoGoffFlaccoCarrMontana1231139376737068646362535252515149484642413939
NAMEGPYDSCMPATTPCTAVGYDS/GTDINTRTGTD%INT%SCKSCKY
Drew BreesDrew Brees12343,9673,5855,12969.98.6357.5328108108.66.42.11741,201
Tom BradyTom Brady11340,0963,2284,72868.38.5354.830268109.66.41.41911,177
Peyton ManningPeyton Manning9332,4082,5633,80267.48.5348.523898103.96.32.6116790
Matt RyanMatt Ryan7626,2962,2163,20169.28.2346.015454103.04.81.71591,083
Philip RiversPhilip Rivers7325,5251,9692,90867.78.8349.716276102.85.62.6132770
Aaron RodgersAaron Rodgers7024,1771,8592,75767.48.8345.419728114.47.11.01721,162
Ben RoethlisbergerBen Roethlisberger6824,5631,9482,89467.38.5361.215972101.55.52.5153999
Matthew StaffordMatthew Stafford6422,5991,7572,69165.38.4353.114853101.65.52.0120856
Dan MarinoDan Marino6322,4301,6532,67361.88.4356.01678596.26.23.276609
Brett FavreBrett Favre6221,0891,6482,53665.08.3340.114963100.15.92.599701
Kirk CousinsKirk Cousins5318,6881,5252,15670.78.7352.612737109.65.91.7109822
Carson PalmerCarson Palmer5218,0371,4022,18464.28.3346.91115596.45.12.5122869
Kurt WarnerKurt Warner5217,9581,3812,03867.88.8345.311362101.15.53.0120799
Eli ManningEli Manning5118,1351,4152,19264.68.3355.61146894.85.23.180528
Dan FoutsDan Fouts5117,8461,2542,02062.18.8349.91087992.25.33.9
Warren MoonWarren Moon4917,2911,2832,07761.88.3352.91007090.34.83.4105758
Patrick MahomesPatrick Mahomes4817,2061,3541,96668.98.8358.513037110.16.61.974489
Tony RomoTony Romo4615,5831,1851,77366.88.8338.811248104.26.32.786599
Jared GoffJared Goff4214,8361,1651,70068.58.7353.29923109.35.81.462432
Joe FlaccoJoe Flacco4113,7991,1341,78763.57.7336.6863894.34.82.179541
Derek CarrDerek Carr3913,3551,0511,61465.18.3342.4773198.74.81.965371
Joe MontanaJoe Montana3913,8241,0601,56567.78.8354.510244105.36.52.873511
Drew BledsoeDrew Bledsoe3712,8009951,59562.48.0345.9774891.14.83.081597
John ElwayJohn Elway3612,1239091,45562.58.3336.8753695.75.22.585675
Andy DaltonAndy Dalton3411,6468921,36065.68.6342.57533100.75.52.489588
Andrew LuckAndrew Luck
Jameis WinstonJameis Winston
Kerry CollinsKerry Collins
Donovan McNabbDonovan McNabb
Trent GreenTrent Green
Vinny TestaverdeVinny Testaverde
Matt SchaubMatt Schaub
Boomer EsiasonBoomer Esiason
Josh AllenJosh Allen
Dak PrescottDak Prescott
Steve YoungSteve Young
Justin HerbertJustin Herbert
Jay CutlerJay Cutler
Marc BulgerMarc Bulger
Joe BurrowJoe Burrow
Mark BrunellMark Brunell
Jim EverettJim Everett
Jim KellyJim Kelly
Johnny UnitasJohnny Unitas
Russell WilsonRussell Wilson
Ryan TannehillRyan Tannehill
Sonny JurgensenSonny Jurgensen
Carson WentzCarson Wentz
Ryan FitzpatrickRyan Fitzpatrick
Rich GannonRich Gannon
StatMuse has game-level data for passing yards going back to the 1950 season.

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