9 players are tied for the most turnovers in a game, with 6 turnovers. The first three are Jameis Winston on October 13, 2019, Ryan Fitzpatrick on September 25, 2016 and Philip Rivers on October 15, 2012.

most turnover by a player in a regular-season game by 2 oponents

NAME	TOV	DATE	TM		OPP	LOST	INT	YDS	TD	RUSH YDS	RUSH TD	REC YDS	REC TD	KR YDS	KR TD	PR YDS	PR TD
Jameis Winston	6	10/13/2019	TB	vs	CAR	1	5	1	0	1	0	0	0	0	0	0	0
Ryan Fitzpatrick	6	9/25/2016	NYJ	@	KC	0	6	22	0	22	0	0	0	0	0	0	0
Philip Rivers	6	10/15/2012	SD	vs	DEN	2	4	0	0	0	0	0	0	0	0	0	0
Kurt Warner	6	11/1/2009	ARI	vs	CAR	1	5	8	0	8	0	0	0	0	0	0	0
Kurt Warner	6	9/28/2008	ARI	@	NYJ	3	3	0	0	0	0	0	0	0	0	0	0
Peyton Manning	6	11/11/2007	IND	@	SD	0	6	0	0	0	0	0	0	0	0	0	0
Gus Frerotte	6	10/14/2007	STL	@	BAL	1	5	2	0	2	0	0	0	0	0	0	0
Tony Romo	6	10/8/2007	DAL	@	BUF	1	5	7	0	7	0	0	0	0	0	0	0
Rex Grossman	6	10/16/2006	CHI	@	ARI	2	4	-7	0	-7	0	0	0	0	0	0	0
Chris Chandler	6	12/12/2004	STL	@	CAR	0	6	2	0	2	0	0	0	0	0	0	0
Jared Goff	5	11/10/2024	DET	@	HOU	0	5	2	0	2	0	0	0	0	0	0	0
Trevor Lawrence	5	10/2/2022	JAX	@	PHI	4	1	8	0	7	0	0	0	0	0	0	0
Joe Burrow	5	9/11/2022	CIN	vs	PIT	1	4	47	0	47	0	0	0	0	0	0	0
Justin Fields	5	10/24/2021	CHI	@	TB	2	3	36	0	38	0	0	0	0	0	0	0
Sam Darnold	5	10/21/2019	NYJ	vs	NE	1	4	-1	0	-1	0	0	0	0	0	0	0
Case Keenum	5	9/23/2019	WAS	vs	CHI	2	3	3	0	3	0	0	0	0	0	0	0
Patrick Mahomes	5	11/19/2018	KC	@	LAR	2	3	28	0	28	0	0	0	0	0	0	0
Josh Rosen	5	10/18/2018	ARI	vs	DEN	2	3	14	0	14	0	0	0	0	0	0	0
Blake Bortles	5	10/7/2018	JAX	@	KC	1	4	34	1	34	1	0	0	0	0	0	0
Ben Roethlisberger	5	9/9/2018	PIT	@	CLE	2	3	16	0	16	0	0	0	0	0	0	0
Nathan Peterman	5	11/19/2017	BUF	@	LAC	0	5	1	0	4	0	0	0	0	0	0	0
Matthew Stafford	5	10/15/2017	DET	@	NO	2	3	4	0	4	0	0	0	0	0	0	0
Ben Roethlisberger	5	10/8/2017	PIT	vs	JAX	0	5	1	0	1	0	0	0	0	0	0	0
Andy Dalton	5	9/10/2017	CIN	vs	BAL	1	4	2	0	2	0	0	0	0	0	0	0
Matt Barkley	5	12/24/2016	CHI	vs	WAS	0	5	0	0	0	0	0	0	0	0	0	0
Philip Rivers
Russell Wilson
Jameis Winston
Eli Manning
Kirk Cousins
Eli Manning
Matt McGloin
Joe Flacco
Mark Sanchez
Josh Freeman
John Skelton
Jake Locker
Drew Brees
Matt Ryan
Tony Romo
Ben Roethlisberger
Ryan Fitzpatrick
Matt Hasselbeck
Jay Cutler
Matt Hasselbeck
Keith Null
Josh Freeman
Mark Sanchez
Jay Cutler
Matthew Stafford