NVIDIA (NVDA) has had the highest return between October 1, 2023 and October 31, 2024 by a mega-cap US stock, returning 217.1%.

The S&P 500 (GSPC) has returned 46.4% since January 13, 2023.

Madrigal Pharmaceuticals (MDGL) had the highest return between November 1, 2022 and December 31, 2022 by a mid-cap US stock, returning 301.6%.

Terawulf (WULF) had the lowest return in June 2022 by a mid-cap US stock or mid-cap US stock, returning -62.1%.

Terawulf (WULF) had the lowest return in June 2022 by a mid-cap US stock or mid-cap US stock, returning -62.1%.

The closing price for Coinbase Global (COIN) between April 1, 2024 and October 31, 2024 is $198.93, yesterday. It is down 24% in that time. The latest price is $206.61.

Tectonic Therapeutic (TECX) has had the highest return since January 1, 2024 by a US stock, returning 4,313,650%.

The closing price for Bitcoin (BTC) between April 1, 2024 and October 31, 2024 is $66,432.20, yesterday. It is down 6.9% in that time. The latest price is $67,786.27.

The closing price for Bitcoin (BTC) in 2018 was $3,742.70, on December 31, 2018. It was down 73.5% for the year. The latest price is $67,786.27.

Sorry, I don't have the answer to that one.

Trump Media & Technology (DJT) had the highest return between December 1, 2021 and January 31, 2022 by a mid-cap US stock, returning 76.2%.

Alpha Metallurgical Resources (AMR) had the highest return between December 1, 2021 and January 31, 2024 by a mid-cap US stock, returning 780.4%.

Verona Pharma PLC ADR (VRNA) had the highest return in December 2021 by a mid-cap US stock, returning 39.1%.

NVIDIA (NVDA) had its best year between January 1, 2023 and December 31, 2023 last year, returning 233.6%.

Sorry, I don't have the answer to that one.