Perspective Therapeutics (CATX) had the highest return in 2005 by a US stock, returning 2,416,566.7%.

The average closing price for Bitcoin (BTC) in 2016 was $568.49. It was up 123.8% for the year.

Santech (STEC) has had the highest return between October 11, 2025 and January 9, 2026 by a US stock in the Nasdaq Composite (IXIC), returning 26,161.2%.

Digital Ally (DGLY) has had the highest return since January 1, 2026 by a US stock in the Nasdaq Composite (IXIC), returning 321.8%.

Enphase Energy (ENPH) had the highest return between 2017 and 2019 by a large-cap US stock, returning 2,461.8%.

The closing price for Monster Beverage (MNST) in 1994 was $0.02, on December 30, 1994. It was down 30.4% for the year. The latest price is $61.72.

Madrigal Pharmaceuticals (MDGL) had the highest return between 2017 and 2018 by a large-cap US stock, returning 654%.

MicroStrategy (MSTR) had the highest return between March 2, 2024 and March 31, 2024 by a large-cap US stock, returning 42%.

Alphabet Inc Class C (GOOG) had the highest return between March 2, 2024 and March 31, 2024 by a mega-cap US stock, returning 11.5%.

The S&P 500 (GSPC) has returned 80% since 2021.

The S&P 500 (GSPC) has returned 80% since 2021.

The average closing price for Bitcoin (BTC) in July 2019 was $10,669.34. It was down 6.6% for the month. The latest price is $67,390.02.

MSCI (MSCI) returned 2,114.9% between 2002 and 2022.

MSCI (MSCI) returned 2,114.9% between 2002 and 2022.

Sorry, I don't have the answer to that one.