YPF Sociedad Anonima (YPF) has the highest short interest by a large-cap US stock, with 6,710.13% of float sold short (6.541M shares).

YPF Sociedad Anonima (YPF) has the highest short interest by a large-cap US stock, with 6,710.13% of float sold short (6.541M shares).
Large-cap stocks are treated as having a market cap of $10B+.