Soleno Therapeutics (SLNO) had the highest return last year by a US stock in the Nasdaq Composite (IXIC) with a market cap of $1B+, returning 1,825.8%.
![money illustration](https://cdn.statmuse.com/finance/asset_img/stocks-generic-wax-candle--znlugoth.png)
Soleno Therapeutics (SLNO) had the highest return last year by a US stock in the Nasdaq Composite (IXIC) with a market cap of $1B+, returning 1,825.8%.