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8 players were tied for the most games with 4+ goals versus the Senators, with 1 game. The first three are Nathan MacKinnon, Jack Eichel and Auston Matthews.

which player has the most 4 goal games against the ottawa senators
Interpreted as:
Which player has the most 4 or more goal regular-season games against the ottawa senators?
MacKinnonEichelMatthewsFranzenVanekOvechkinBondraPerreault11111111
NAMEGPGAP+/-PIMPPGPPASHGSHAGWGOTGSS%FOWFOFOW%HITBKSTKAGVATOI/GP
Nathan MacKinnonNathan MacKinnon1415+10210000944.491850.0001322:51
Jack EichelJack Eichel1404+40000010580.082040.0101119:57
Auston MatthewsAuston Matthews1404+30000000666.761346.2002017:37
Johan FranzenJohan Franzen1505+302000101050.000000018:28
Thomas VanekThomas Vanek1404+24100010666.700010116:06
Alex OvechkinAlex Ovechkin1415+20100010580.000201221:21
Peter BondraPeter Bondra1404+22200010580.000102119:53
Yanic PerreaultYanic Perreault1404+20101010666.7

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