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The Buffalo Sabres and the Atlanta Thrashers were tied for the highest goal differential in a game in 2005-06, with a differential of 9 goals.

nhl largest goal differential in a game 2006
Interpreted as:
NHL largest goal differential in a regular-season game 2006
1/14/2006Sabres11/12/2005Thrashers11/4/2005Stars10/29/2005Senators10/14/2005Maple Leafs4/1/2006Maple Leafs1/25/2006Penguins1/21/2006Senators1/14/2006Canucks11/3/2005Flyers10/8/2005Thrashers4/16/2006Sabres4/3/2006Oilers3/21/2006Sharks3/2/2006Senators2/28/2006Panthers2/8/2006Red Wings2/4/2006Predators1/31/2006Hurricanes1/28/2006Lightning1/28/2006Rangers1/12/2006Kings9988877777766666666666

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