The Detroit Red Wings have the highest goal differential by a team in a game, with a differential of 15 goals against the Rangers on January 23, 1944.

largest goal differential in a single regular-season game

TEAM	DIFF	DATE	TM		OPP	RESULT	G	GA	PPG	PPO	OPP PPG	OPP PPO	S	SA
Red Wings	15	1/23/1944	DET	vs	NYR	W 15-0	15	0	2		0
Oilers	13	11/8/1985	EDM	vs	VAN	W 13-0	13	0	0	1	0	6	44	29
North Stars	13	11/11/1981	MNS	vs	WIN	W 15-2	15	2	5	7	1	6	51	42
Maple Leafs	13	1/2/1971	TOR	vs	DET	W 13-0	13	0	4		0		49	31
Maple Leafs	13	3/16/1957	TOR	vs	NYR	W 14-1	14	1	2		1		47	33
Canadiens	13	3/3/1920	MTL	@	QBD	W 16-3	16	3
Flames	12	2/10/1993	CGY	vs	SJS	W 13-1	13	1	0	3	1	5	36	27
Red Wings	12	12/4/1987	DET	vs	CHI	W 12-0	12	0	2	7	0	6	45	19
Canadiens	12	2/22/1979	MTL	vs	PIT	W 12-0	12	0	1	2	0	2	37	25
Sabres	12	12/21/1975	BUF	vs	WSH	W 14-2	14	2	1		1		50	16
Black Hawks	12	1/30/1969	CHI	@	PHI	W 12-0	12	0	1		0		49	37
Canucks	11	3/1/1992	VAN	vs	CGY	W 11-0	11	0	6	10	0	3	28	30
Penguins	11	12/26/1991	PIT	vs	TOR	W 12-1	12	1	3	4	0	4	32	31
Kings	11	11/29/1984	LAK	vs	VAN	W 12-1	12	1	6	8	0	6	44	23
Flyers	11	10/18/1984	PHI	vs	VAN	W 13-2	13	2	4	9	1	3	58	19
Whalers	11	2/12/1984	HFD	vs	EDM	W 11-0	11	0	6	6	0	6	30	28
Flames	11	4/1/1982	CGY	vs	CLR	W 11-0	11	0	3	4	0	2	35	18
Flyers	11	10/20/1977	PHI	vs	PIT	W 11-0	11	0	1	3	0	2	54	20
Canadiens	11	4/2/1977	MTL	vs	WSH	W 11-0	11	0	0		0		42	24
Penguins	11	3/15/1975	PIT	vs	WSH	W 12-1	12	1	0		0		65	24
Bruins	11	12/14/1974	BOS	vs	WSH	W 12-1	12	1	2		1		48	16
Maple Leafs	11	11/25/1972	TOR	vs	CGS	W 11-0	11	0	3		0		43	37
Rangers	11	11/21/1971	NYR	vs	CGS	W 12-1	12	1	1		0		52	16
Bruins	11	1/18/1964	BOS	@	TOR	W 11-0	11	0	0		0		38	26
Canadiens	11	1/9/1954	MTL	vs	CHI	W 12-1	12	1	5		0
Maple Leafs
Bruins
Senators
Blue Jackets
Capitals
Flames
Avalanche