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Jameis Winston and Peyton Manning are tied for the most games by a quarterback with 450+ passing yards and 4+ passing touchdowns, with 3 games.

which quarterback has the most career games with 450 or more passing yards and 4 or more passing tds
Interpreted as:
Which quarterback has the most career regular-season games with 450 or more passing yards and 4 or more passing tds?
WinstonManningCousinsGoffBreesMarinoKramerStroudTagovailoaBurrowPrescottFolesMahomesLuckWilsonCarrRyanRoethlisbergerRomoRodgersManningSchaub3322222111111111111111
NAMEGPYDSTDCMPATTPCTAVGYDS/GINTRTGTD%INT%SCKSCKY
Jameis WinstonJameis Winston31,411129514565.59.7470.37104.78.34.8641
Peyton ManningPeyton Manning31,413168313362.410.6471.03128.512.02.3420
Kirk CousinsKirk Cousins296987611267.98.7484.53107.37.12.71166
Jared GoffJared Goff295910649269.610.4479.50139.710.90.0430
Drew BreesDrew Brees297011739973.79.8485.03128.811.13.015
Dan MarinoDan Marino29439589958.69.5471.53108.39.13.0553
Tommy KramerTommy Kramer29468588469.011.3473.01133.39.51.2
C.J. StroudC.J. Stroud14705304271.411.2470.00147.811.90.0327
Tua TagovailoaTua Tagovailoa14696365072.09.4469.02124.112.04.018
Joe BurrowJoe Burrow15254374680.411.4525.00143.28.70.0327
Dak PrescottDak Prescott15024415870.78.7502.01112.96.91.7321
Nick FolesNick Foles14714354971.49.6471.01120.48.22.019
Patrick MahomesPatrick Mahomes14786334671.710.4478.03117.613.06.5330
Andrew LuckAndrew Luck14644406264.57.5464.00108.56.50.0427
Russell WilsonRussell Wilson14524264163.411.0452.01123.29.82.426
Derek CarrDerek Carr15134405967.88.7513.00117.46.80.0215
Matt RyanMatt Ryan15034283775.713.6503.01142.010.82.7322
Ben RoethlisbergerBen Roethlisberger15226404981.610.7522.00150.612.20.000
Tony RomoTony Romo15065253669.414.1506.01140.013.92.8436
Aaron RodgersAaron Rodgers14804344281.011.4480.00146.09.50.0439
Eli ManningEli Manning14504274264.310.7450.03102.39.57.1322
Matt SchaubMatt Schaub15275435578.29.6527.02121.79.13.6223
Matt FlynnMatt Flynn14806314470.510.9480.01136.413.62.3311
Matthew StaffordMatthew Stafford15205365961.08.8520.02103.88.53.4218
Tom BradyTom Brady15174324866.710.8517.01121.68.32.111
Matt CasselMatt Cassel
Billy VolekBilly Volek
Donovan McNabbDonovan McNabb
Jake PlummerJake Plummer
Marc BulgerMarc Bulger
Tommy MaddoxTommy Maddox
Gus FrerotteGus Frerotte
Steve YoungSteve Young
Joe MontanaJoe Montana
Ken O'BrienKen O'Brien
Doug WilliamsDoug Williams
Joe NamathJoe Namath
Y.A. TittleY.A. Tittle
George BlandaGeorge Blanda
Norm Van BrocklinNorm Van Brocklin
StatMuse has game-level data for passing touchdowns and passing yards going back to the 1950 season.

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