| NAME | HOF | SEASON | TM | GP | CMP | ATT | PCT | YDS | AVG | YDS/G | TD | INT | RTG | TD% | INT% | SCK | SCKY | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Peyton Manning | 2021 | 1998 |  IND | 16 | 326 | 575 | 56.7 | 3,739 | 6.5 | 233.7 | 26 | 28 | 71.2 | 4.5 | 4.9 | 22 | 109 |
| Peyton Manning | 2021 | 1999 | IND | 16 | 331 | 533 | 62.1 | 4,135 | 7.8 | 258.4 | 26 | 15 | 90.7 | 4.9 | 2.8 | 14 | 116 |
| Peyton Manning | 2021 | 2000 | IND | 16 | 357 | 571 | 62.5 | 4,413 | 7.7 | 275.8 | 33 | 15 | 94.7 | 5.8 | 2.6 | 20 | 131 |
| Peyton Manning | 2021 | 2001 | IND | 16 | 343 | 547 | 62.7 | 4,131 | 7.6 | 258.2 | 26 | 23 | 84.1 | 4.8 | 4.2 | 29 | 232 |
| Peyton Manning | 2021 | 2002 | IND | 16 | 392 | 591 | 66.3 | 4,200 | 7.1 | 262.5 | 27 | 19 | 88.8 | 4.6 | 3.2 | 23 | 145 |
| Peyton Manning | 2021 | 2003 | IND | 16 | 379 | 566 | 67.0 | 4,267 | 7.5 | 266.7 | 29 | 10 | 99.0 | 5.1 | 1.8 | 18 | 107 |
| Peyton Manning | 2021 | 2004 | IND | 16 | 336 | 497 | 67.6 | 4,557 | 9.2 | 284.8 | 49 | 10 | 121.1 | 9.9 | 2.0 | 13 | 101 |
| Peyton Manning | 2021 | 2005 | IND | 16 | 305 | 453 | 67.3 | 3,747 | 8.3 | 234.2 | 28 | 10 | 104.1 | 6.2 | 2.2 | 17 | 81 |
| Peyton Manning | 2021 | 2006 | IND | 16 | 362 | 557 | 65.0 | 4,397 | 7.9 | 274.8 | 31 | 9 | 101.0 | 5.6 | 1.6 | 14 | 86 |
| Peyton Manning | 2021 | 2007 | IND | 16 | 337 | 515 | 65.4 | 4,040 | 7.8 | 252.5 | 31 | 14 | 98.0 | 6.0 | 2.7 | 21 | 124 |
| Peyton Manning | 2021 | 2008 | IND | 16 | 371 | 555 | 66.8 | 4,002 | 7.2 | 250.1 | 27 | 12 | 95.0 | 4.9 | 2.2 | 14 | 86 |
| Peyton Manning | 2021 | 2009 | IND | 16 | 393 | 571 | 68.8 | 4,500 | 7.9 | 281.3 | 33 | 16 | 99.9 | 5.8 | 2.8 | 10 | 74 |
| Peyton Manning | 2021 | 2010 | IND | 16 | 450 | 679 | 66.3 | 4,700 | 6.9 | 293.8 | 33 | 17 | 91.9 | 4.9 | 2.5 | 16 | 91 |
 | Peyton Manning | 2021 | 2012 |  DEN | 16 | 400 | 583 | 68.6 | 4,659 | 8.0 | 291.2 | 37 | 11 | 105.8 | 6.3 | 1.9 | 21 | 137 |
| Peyton Manning | 2021 | 2013 | DEN | 16 | 450 | 659 | 68.3 | 5,477 | 8.3 | 342.3 | 55 | 10 | 115.1 | 8.3 | 1.5 | 18 | 120 |
| Peyton Manning | 2021 | 2014 | DEN | 16 | 395 | 597 | 66.2 | 4,727 | 7.9 | 295.4 | 39 | 15 | 101.5 | 6.5 | 2.5 | 17 | 118 |
| Peyton Manning | 2021 | 2015 | DEN | 10 | 198 | 331 | 59.8 | 2,249 | 6.8 | 224.9 | 9 | 17 | 67.9 | 2.7 | 5.1 | 16 | 95 |
| Average | 118.9 | 15.6 | 360.3 | 551.8 | 65.3 | 4231.8 | 7.7 | 270.5 | 31.7 | 14.8 | 96.5 | 5.7 | 2.7 | 17.8 | 114.9 | |||
| Total | 2021 | 266 | 6,125 | 9,380 | 65.3 | 71,940 | 7.7 | 270.5 | 539 | 251 | 96.5 | 5.7 | 2.7 | 303 | 1,953 |