Since 2000, the Cincinnati Bengals have rushed for the most yards by a team in a game, with 407 yards versus the Broncos on October 22, 2000.

most rushing yards by a team in a single regular-season game since 2000

TEAM	RUSH YDS	DATE	TM		OPP	RESULT	ATT	YPC	RUSH TD
Bengals	407	10/22/2000	CIN	vs	DEN	W 31-21	37	11.0	4
Ravens	404	1/3/2021	BAL	@	CIN	W 38-3	54	7.5	2
Vikings	378	11/4/2007	MIN	vs	SD	W 35-17	43	8.8	4
Jaguars	375	12/10/2006	JAX	vs	IND	W 44-17	42	8.9	4
Eagles	363	11/27/2022	PHI	vs	GB	W 40-33	49	7.4	3
49ers	355	12/20/2014	SF	vs	SD	L 35-38	40	8.9	3
Chiefs	352	12/23/2012	KC	vs	IND	L 13-20	44	8.0	1
Browns	351	12/20/2009	CLE	@	KC	W 41-34	49	7.2	3
Dolphins	350	9/24/2023	MIA	vs	DEN	W 70-20	43	8.1	5
Seahawks	350	11/9/2014	SEA	vs	NYG	W 38-17	45	7.8	5
Ravens	343	9/14/2003	BAL	vs	CLE	W 33-13	41	8.4	2
Rams	337	11/11/2001	STL	vs	CAR	W 48-14	41	8.2	4
Colts	335	12/22/2024	IND	vs	TEN	W 38-30	50	6.7	4
Titans	332	10/19/2008	TEN	@	KC	W 34-10	40	8.3	4
Raiders	328	10/24/2010	OAK	@	DEN	W 59-14	52	6.3	5
Jets	323	10/7/2018	NYJ	vs	DEN	W 34-16	38	8.5	1
Panthers	320	12/24/2022	CAR	vs	DET	W 37-23	43	7.4	3
Seahawks	320	10/16/2005	SEA	vs	HOU	W 42-10	42	7.6	5
Seahawks	319	11/11/2001	SEA	vs	OAK	W 34-27	42	7.6	3
Jets	318	10/18/2009	NYJ	vs	BUF	L 13-16	40	8.0	1
Falcons	318	9/7/2008	ATL	vs	DET	W 34-21	42	7.6	3
Chiefs	317	1/3/2010	KC	@	DEN	W 44-24	35	9.1	3
Jets	316	10/25/2009	NYJ	@	OAK	W 38-0	54	5.9	4
Eagles	314	11/24/2024	PHI	@	LAR	W 37-20	45	7.0	3
Titans	314	10/30/2022	TEN	@	HOU	W 17-10	45	7.0	2
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