Between July 11, 2020 and July 11, 2025, Saquon Barkley has the most rushing yards by a running back in a game, with 255 yards versus the Rams on November 24.

Between July 11, 2020 and July 11, 2025, Saquon Barkley has the most rushing yards by a running back in a game, with 255 yards versus the Rams on November 24.