Between July 25, 2020 and July 25, 2025, Saquon Barkley has rushed for the most yards by a running back in a game, with 255 yards against the Rams on November 24.

Between July 25, 2020 and July 25, 2025, Saquon Barkley has rushed for the most yards by a running back in a game, with 255 yards against the Rams on November 24.