Since 1980, 8 players are tied for the most home runs in a game, with 4 home runs. The first three are J.D. Martinez on September 4, 2017, Scooter Gennett on June 6, 2017 and Josh Hamilton on May 8, 2012.

what are the most hr in a game since 1980
Interpreted as:
What are the most hr by a player in a regular-season game since 1980?

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