5 teams are tied for the most homers in a loss, with 7 homers. The first three are the Los Angeles Angels on August 4, 2022, the Minnesota Twins on July 28, 2021 and the Toronto Blue Jays on August 12, 2020.

most home runs in a lose mlb history single game
Interpreted as:
most home runs in a lose MLB history single regular-season game

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