47 players are tied for the most hits in a game in the 4th inning, with 2 hits. The first three are TJ Friedl on September 14, Weston Wilson on August 15 and Jose Altuve on May 24.

most hits by a player in the 4th inning in a single game
Interpreted as:
most hits by a player in the 4th inning in a single regular-season game

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