Between January 9, 2006 and January 9, 2026, the Tampa Bay Buccaneers have their lowest point differential in a game versus the 49ers on October 9, 2011, with a -45-point differential.
Between January 9, 2006 and January 9, 2026, the Tampa Bay Buccaneers have their lowest point differential in a game versus the 49ers on October 9, 2011, with a -45-point differential.