8 quarterbacks are tied for the most passing touchdowns in a game, with 7 touchdowns. The first three are Drew Brees on November 1, 2015, Nick Foles on November 3, 2013 and Peyton Manning on September 5, 2013.

most touchdowns thrown in one game in nfl history
Interpreted as:
most touchdowns thrown by a player in one regular-season game in NFL history

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