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Alan Shearer has tallied the most career goals in the Premier League against Big Six opponents, with 56 goals.

most goals against big 6 in history

Interpreted as:

most goals by a player against big 6 in history

	NAME	G	M	MIN	START	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
	Alan Shearer	56	129	11,314	126	0.43	19	75	7
	Mohamed Salah	49	77	6,352	72	0.64	22	71	11
	Jamie Vardy	45	108	8,408	95	0.42	10	55	8	0	188	92	8	2,258	328	88
	Wayne Rooney	45	135	10,635	117	0.33	14	59	6
	Sergio Agüero	44	75	5,630	69	0.59	8	52	6
	Jimmy Floyd Hasselbaink	41	81	5,793	66	0.51	11	52	3
	Harry Kane	39	81	7,007	78	0.48	9	48	11
	Thierry Henry	34	61	5,181	57	0.56	13	47	3
	Dion Dublin	34	92	7,047	79	0.37	13	47	5
	Robbie Fowler	33	90	6,386	70	0.37	10	43	3
	Andy Cole	32	109	8,470	95	0.29	13	45	0
	Darren Bent	31	76	5,287	56	0.41	5	36	4
	Les Ferdinand	31	93	6,907	78	0.33	13	44	0
	Sadio Mané	29	79	6,196	71	0.37	9	38	0	0	153	76	4	3,686	286	65
	Robin van Persie	28	75	5,554	61	0.37	11	39	3
	Jermain Defoe	28	136	8,646	91	0.21	6	34	5
	Marcus Rashford	27	82	5,719	64	0.33	9	36	4	0	130	65	6	2,436	274	39
	Son Heung-min	27	88	6,420	76	0.31	9	36	1	0	173	79	5	3,170	289	59
	Mark Viduka	27	74	5,413	59	0.36	3	30	2
	Frank Lampard	26	158	12,798	144	0.16	21	47	10
	Roberto Firmino	25	70	5,255	62	0.36	9	34	1	0	149	69	4	3,313	329	24
	Teddy Sheringham	25	106	7,846	88	0.24	12	37	5
	Christian Benteke	24	83	5,792	64	0.29	9	33	1
	Kevin De Bruyne	23	77	5,896	67	0.30	19	42	2
	Gylfi Þór Sigurðsson	23	98	7,452	82	0.23	11	34	5
	Theo Walcott
	Peter Crouch
	Michael Owen
	Nicolas Anelka
	Brian Deane
	Raheem Sterling
	Emmanuel Adebayor
	Yakubu Aiyegbeni
	Robbie Keane
	Steven Gerrard
	Kevin Davies
	James Beattie
	Dwight Yorke
	Didier Drogba
	Cristiano Ronaldo
	Kevin Phillips
	Emile Heskey
	Matt Le Tissier
	Michail Antonio
	Paolo Di Canio
	Erling Haaland
	Ollie Watkins
	Fernando Torres
	Tim Cahill
	Louis Saha

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